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| BORON NEUTRON CAPTURE THERAPY
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| ( BNCT)
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| The BNCT project at LVR-15 reactor of NRI for treatment of human brain
gliomas is before start of clinical trials. A survey of present conditions
is included, the attention is devoted to BNCT facility with epithermal neutron
beam first of all. The different materials for filter composition were studied,
the calculational methods have been used for the determination of neutron
and gamma rays in the reactor geometry. Some configurations were experimentally
verified. The effort for improvement of epithermal neutron beam parameters
in configuration 1998 was concentrated to block of filters remodeling, improvement
of collimator-shutter geometry, the choice of optimal reactor core edge
configuration. Awaited results from experiment in June 1999 are described. |
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| BNCT at LVR - 15 reactor |
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| The BNCT interdisciplinary group in the Czech republic decided as a first
priority to initiate the glioma clinical trial at the LVR reactor of NRI.
The principal aim now is to prepare the Phase I trial, to establish maximum
tolerated dose by healthy tissue when irradiating with BSH drug. The activity
has been concentrated in this final stage also on improvement of the parameters
of the beam. The treatment protocol was prepared and put forward to corresponding
authorities for approval. |
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| Epithermal neutron beam configuration
1998 |
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